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ONTOLOGY REPORT - ANNOTATIONS

Term:tRNA methylation
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Accession:GO:0030488 term browser browse the term
Definition:The posttranscriptional addition of methyl groups to specific residues in a tRNA molecule.

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tRNA methylation term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Alkbh8 alkB homolog 8, tRNA methyltransferase involved_in IEA Ensembl
TreeGrafter		 GO_REF:0000107 GO_REF:0000118 NCBI chrNW_004624784:2,255,492...2,373,824 JBrowse link
G Bcdin3d BCDIN3 domain containing RNA methyltransferase involved_in ISO (PMID:28119416), (PMID:31919512) UniProt PMID:28119416 PMID:31919512 NCBI chrNW_004624816:2,447,703...2,455,543
Ensembl chrNW_004624816:2,447,739...2,453,228 		JBrowse link
G Ftsj1 FtsJ RNA 2'-O-methyltransferase 1 involved_in IEA UniProt
TreeGrafter		 GO_REF:0000117 GO_REF:0000118 NCBI chrNW_004624893:297,312...308,772
Ensembl chrNW_004624893:299,020...303,773 		JBrowse link
G Lcmt2 leucine carboxyl methyltransferase 2 involved_in IEA TreeGrafter GO_REF:0000118 NCBI chrNW_004624804:10,436,000...10,438,806
Ensembl chrNW_004624804:10,436,731...10,438,785 		JBrowse link
G Mettl1 methyltransferase 1, tRNA methylguanosine involved_in IEA UniProt
TreeGrafter		 GO_REF:0000104 GO_REF:0000118 NCBI chrNW_004624802:10,172,092...10,175,534
Ensembl chrNW_004624802:10,172,072...10,177,186 		JBrowse link
G Mettl2a methyltransferase 2A, tRNA N3-cytidine involved_in IEA Ensembl GO_REF:0000107 NCBI chrNW_004624849:6,059,350...6,072,198 JBrowse link
G Mettl6 methyltransferase 6, tRNA N3-cytidine involved_in ISO (PMID:32923617), (PMID:34268557), (PMID:34862464), (PMID:34922197)
(PMID:28655767)		 UniProt
MGI		 PMID:28655767 PMID:32923617 PMID:34268557 PMID:34862464 PMID:34922197 NCBI chrNW_004624822:5,253,659...5,349,292
Ensembl chrNW_004624822:5,254,938...5,282,742 		JBrowse link
G Mto1 mitochondrial tRNA translation optimization 1 involved_in IEA TreeGrafter GO_REF:0000118 NCBI chrNW_004624819:686,759...729,765
Ensembl chrNW_004624819:687,050...722,993 		JBrowse link
G Nop2 NOP2 nucleolar protein involved_in IEA TreeGrafter GO_REF:0000118 NCBI chrNW_004624860:3,273,944...3,284,150 JBrowse link
G Nsun2 NOP2/Sun RNA methyltransferase 2 involved_in IEA Ensembl
TreeGrafter
UniProt		 GO_REF:0000107 GO_REF:0000117 GO_REF:0000118 NCBI chrNW_004624751:4,288,436...4,309,172
Ensembl chrNW_004624751:4,287,249...4,309,438 		JBrowse link
G Nsun6 NOP2/Sun RNA methyltransferase 6 involved_in ISO (PMID:28531330) UniProt PMID:28531330 NCBI chrNW_004624796:9,433,005...9,539,757
Ensembl chrNW_004624796:9,438,338...9,501,296 		JBrowse link
G Tarbp1 TAR (HIV-1) RNA binding protein 1 involved_in IEA InterPro
TreeGrafter		 GO_REF:0000002 GO_REF:0000118 NCBI chrNW_004624775:15,874,543...15,939,275
Ensembl chrNW_004624775:15,874,551...15,939,272 		JBrowse link
G Thada THADA armadillo repeat containing involved_in IEA TreeGrafter GO_REF:0000118 NCBI chrNW_004624738:24,750,657...25,087,278
Ensembl chrNW_004624738:24,751,466...25,083,909 		JBrowse link
G Thumpd2 THUMP domain containing 2 involved_in IEA TreeGrafter GO_REF:0000118 NCBI chrNW_004624738:21,238,535...21,287,491
Ensembl chrNW_004624738:21,237,709...21,287,551 		JBrowse link
G Thumpd3 THUMP domain containing 3 involved_in IEA TreeGrafter GO_REF:0000118 NCBI chrNW_004624731:4,052,618...4,078,639
Ensembl chrNW_004624731:4,052,631...4,077,486 		JBrowse link
G Trdmt1 tRNA aspartic acid methyltransferase 1 involved_in
acts_upstream_of_or_within		 ISO (MGI:6194005|PMID:22885326)
(PMID:16424344)		 UniProt
MGI		 PMID:16424344 PMID:22885326 MGI:6194005 NCBI chrNW_004624796:10,630,982...10,712,689
Ensembl chrNW_004624796:10,656,432...10,710,124 		JBrowse link
G Trmo tRNA methyltransferase O involved_in ISO (PMID:25063302) UniProt PMID:25063302 NCBI chrNW_004624825:2,907,695...2,929,259
Ensembl chrNW_004624825:2,907,983...2,931,009 		JBrowse link
G Trmt10a tRNA methyltransferase 10A involved_in ISO (PMID:25053765) UniProt PMID:25053765 NCBI chrNW_004624830:7,515,810...7,529,980
Ensembl chrNW_004624830:7,519,851...7,530,772 		JBrowse link
G Trmt112 tRNA methyltransferase activator subunit 11-2 involved_in IEA TreeGrafter GO_REF:0000118 NCBI chrNW_004624767:21,998,839...21,999,984
Ensembl chrNW_004624767:21,998,812...21,999,984 		JBrowse link
G Trmt12 tRNA methyltransferase 12 homolog involved_in IEA TreeGrafter GO_REF:0000118 NCBI chrNW_004624735:30,739,223...30,740,991 JBrowse link
G Trmt13 tRNA methyltransferase 13 homolog involved_in IEA InterPro
TreeGrafter		 GO_REF:0000002 GO_REF:0000118 NCBI chrNW_004624857:2,930,504...2,950,288
Ensembl chrNW_004624857:2,930,691...2,948,311 		JBrowse link
G Trmt44 tRNA methyltransferase 44 homolog involved_in IEA UniProt
TreeGrafter		 GO_REF:0000104 GO_REF:0000118 NCBI chrNW_004624755:24,035,113...24,052,760
Ensembl chrNW_004624755:24,035,165...24,052,385 		JBrowse link
G Trmt6 tRNA methyltransferase 6 non-catalytic subunit involved_in IEA InterPro
Ensembl		 GO_REF:0000002 GO_REF:0000107 NCBI chrNW_004624741:6,774,767...6,787,461
Ensembl chrNW_004624741:6,775,944...6,788,161 		JBrowse link
G Trmt61a tRNA methyltransferase 61A involved_in IEA InterPro
TreeGrafter
Ensembl		 GO_REF:0000002 GO_REF:0000107 GO_REF:0000118 NCBI chrNW_004624734:1,335,946...1,342,253
Ensembl chrNW_004624734:1,335,091...1,344,714 		JBrowse link
G Trmt61b tRNA methyltransferase 61B involved_in IEA InterPro GO_REF:0000002 NCBI chrNW_004624738:10,788,124...10,809,035
Ensembl chrNW_004624738:10,778,420...10,809,003 		JBrowse link
G Trmt9b tRNA methyltransferase 9B (putative) involved_in IEA TreeGrafter GO_REF:0000118 NCBI chrNW_004624839:3,960,043...4,027,328
Ensembl chrNW_004624839:3,965,378...4,027,548 		JBrowse link
G Wdr6 WD repeat domain 6 involved_in IEA TreeGrafter GO_REF:0000118 NCBI chrNW_004624730:3,058,947...3,063,709
Ensembl chrNW_004624730:3,055,610...3,063,153 		JBrowse link
mitochondrial tRNA methylation term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Hsd17b10 hydroxysteroid 17-beta dehydrogenase 10 involved_in IEA Ensembl GO_REF:0000107 NCBI chrNW_004624909:681,731...684,130
Ensembl chrNW_004624909:681,731...684,237 		JBrowse link
G Trmt10c tRNA methyltransferase 10C, mitochondrial RNase P subunit involved_in ISO (PMID:23042678) ComplexPortal PMID:23042678 NCBI chrNW_004624789:15,420,199...15,424,401
Ensembl chrNW_004624789:15,422,758...15,424,002 		JBrowse link
G Trmt5 tRNA methyltransferase 5 involved_in ISO (PMID:26189817) UniProt PMID:26189817 NCBI chrNW_004624734:40,143,073...40,154,257
Ensembl chrNW_004624734:40,144,291...40,149,362 		JBrowse link
G Trmt61b tRNA methyltransferase 61B involved_in IEA TreeGrafter GO_REF:0000118 NCBI chrNW_004624738:10,788,124...10,809,035
Ensembl chrNW_004624738:10,778,420...10,809,003 		JBrowse link
regulation of tRNA methylation term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Akt1 AKT serine/threonine kinase 1 involved_in IEA Ensembl GO_REF:0000107 NCBI chrNW_004624734:507,880...525,295
Ensembl chrNW_004624734:509,368...525,295 		JBrowse link
tRNA (guanine-N7)-methylation term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Mettl1 methyltransferase 1, tRNA methylguanosine involved_in IEA GOC
Ensembl		 GO_REF:0000107 GO_REF:0000108 NCBI chrNW_004624802:10,172,092...10,175,534
Ensembl chrNW_004624802:10,172,072...10,177,186 		JBrowse link
G Wdr4 WD repeat domain 4 involved_in ISO (PMID:36599982), (PMID:36599985), (PMID:37369656) UniProt PMID:36599982 PMID:36599985 PMID:37369656 NCBI chrNW_004624745:27,795,205...27,822,468
Ensembl chrNW_004624745:27,795,833...27,820,228 		JBrowse link
tRNA C3-cytosine methylation term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Dalrd3 DALR anticodon binding domain containing 3 involved_in IEA TreeGrafter GO_REF:0000118 NCBI chrNW_004624730:3,063,241...3,066,253
Ensembl chrNW_004624730:3,063,245...3,066,453 		JBrowse link
G Mettl8 methyltransferase 8, tRNA N3-cytidine involved_in ISO (PMID:34774131), (PMID:35017528) UniProt PMID:34774131 PMID:35017528 NCBI chrNW_004624787:8,784,206...8,857,834
Ensembl chrNW_004624787:8,780,172...8,829,699 		JBrowse link
tRNA C5-cytosine methylation term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Nsun6 NOP2/Sun RNA methyltransferase 6 involved_in ISO (PMID:26160102) UniProt PMID:26160102 NCBI chrNW_004624796:9,433,005...9,539,757
Ensembl chrNW_004624796:9,438,338...9,501,296 		JBrowse link
tRNA N1-guanine methylation term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Trmt10a tRNA methyltransferase 10A involved_in IEA TreeGrafter GO_REF:0000118 NCBI chrNW_004624830:7,515,810...7,529,980
Ensembl chrNW_004624830:7,519,851...7,530,772 		JBrowse link
G Trmt10b tRNA methyltransferase 10B involved_in IEA TreeGrafter GO_REF:0000118 NCBI chrNW_004624930:1,367,364...1,393,005
Ensembl chrNW_004624930:1,367,386...1,393,003 		JBrowse link
tRNA N2-guanine methylation term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Trmt1 tRNA methyltransferase 1 involved_in IEA TreeGrafter GO_REF:0000118 NCBI chrNW_004624901:650,444...659,921
Ensembl chrNW_004624901:650,202...660,076 		JBrowse link
tRNA nucleoside ribose methylation term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Ftsj1 FtsJ RNA 2'-O-methyltransferase 1 involved_in IEA UniProt GO_REF:0000104 NCBI chrNW_004624893:297,312...308,772
Ensembl chrNW_004624893:299,020...303,773 		JBrowse link
G Thada THADA armadillo repeat containing involved_in ISO (PMID:35559166) UniProt PMID:35559166 NCBI chrNW_004624738:24,750,657...25,087,278
Ensembl chrNW_004624738:24,751,466...25,083,909 		JBrowse link
tRNA wobble base cytosine methylation term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Nsun3 NOP2/Sun RNA methyltransferase 3 involved_in ISO (PMID:27214402), (PMID:27356879), (PMID:27497299) UniProt PMID:27214402 PMID:27356879 PMID:27497299 NCBI chrNW_004624789:6,787,255...6,853,438
Ensembl chrNW_004624789:6,787,234...6,846,201 		JBrowse link
wobble position ribose methylation term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Ftsj1 FtsJ RNA 2'-O-methyltransferase 1 involved_in ISO (PMID:32558197) UniProt PMID:32558197 NCBI chrNW_004624893:297,312...308,772
Ensembl chrNW_004624893:299,020...303,773 		JBrowse link
G Wdr6 WD repeat domain 6 involved_in ISO (PMID:32558197) UniProt PMID:32558197 NCBI chrNW_004624730:3,058,947...3,063,709
Ensembl chrNW_004624730:3,055,610...3,063,153 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  biological_process 15093
    metabolic process 9085
      methylation 186
        macromolecule methylation 71
          RNA methylation 64
            tRNA methylation 37
              5-carbamoylmethyl uridine residue modification 0
              mitochondrial tRNA methylation 4
              positive regulation of tRNA methylation + 0
              regulation of tRNA methylation + 1
              tRNA (guanine-N7)-methylation 2
              tRNA C3-cytosine methylation 2
              tRNA C5-cytosine methylation + 2
              tRNA N1-guanine methylation 2
              tRNA N2-guanine methylation 1
              tRNA m2,2-guanine biosynthesis 0
              tRNA nucleoside ribose methylation + 3
Path 2
Term Annotations click to browse term
  biological_process 15093
    metabolic process 9085
      organic substance metabolic process 8667
        organic cyclic compound metabolic process 4854
          nucleobase-containing compound metabolic process 4436
            nucleic acid metabolic process 3987
              RNA metabolic process 3474
                tRNA metabolic process 169
                  tRNA processing 119
                    tRNA modification 87
                      tRNA methylation 37
                        5-carbamoylmethyl uridine residue modification 0
                        mitochondrial tRNA methylation 4
                        positive regulation of tRNA methylation + 0
                        regulation of tRNA methylation + 1
                        tRNA (guanine-N7)-methylation 2
                        tRNA C3-cytosine methylation 2
                        tRNA C5-cytosine methylation + 2
                        tRNA N1-guanine methylation 2
                        tRNA N2-guanine methylation 1
                        tRNA m2,2-guanine biosynthesis 0
                        tRNA nucleoside ribose methylation + 3
paths to the root